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KMID : 0379520070230030197
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한국독성학회지
2007 Volume.23 No. 3 p.197 ~ p.205
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Role of Transforming Growth Factor-β in Tumor Invasion and Metastasis
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Kim Eun-Sook
Moon Aree
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Abstract
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Cancer metastasis is a major determinant of cancer patient mortality. Mounting evidence favors a strong positive role for TGF-β in human cancer progression. The complex pattern on cross-talk of TGF-β and the related other signaling pathways is an important area of investigation that will ultimately contribute to understanding of the bifunctional role of TGF-β in cancer progression. This review summarizes some of the current understanding of TGF-β signaling with a major focus in its contribution to the tumor cell invasion and metastasis. Five issues are addressed in this review: (1) TGF-β signaling, (2) TGF-β and EMT, (3) TGF-β and MMP, (4) TGF-β and Ras, and (5) Role of TGF-β in invasion and metastasis. Due to the bifunctional cellular effects of TGF-β, as a tumor promoter and a tumor suppressor, more precisely defined TGF-β signaling pathways need to be elucidated. According to the current literature, TGF-β is clearly a major factor stimulating tumor progression through a complex spectrum of the interplay and cross-talk between various signaling molecules. Understanding the role of TGF-β in invasion and metastasis will provide valuable information on establishing strategies to manipulate TGF-β signaling which should be a high priority for the development of anti-metastatic therapeutics.
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KEYWORD
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TGF-β, EMT, MMP, Invasion
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